该研究发现，疫苗接种后的发热风险，与轻度肠道炎症、疫苗接种前有鞭毛的毛螺菌科细菌数量增加以及鞭毛蛋白表达升高相关。发热高发者的肠道微生物群在人类肠道类器官中引发更强的炎症反应，并在无菌小鼠体内诱导依赖鞭毛蛋白的疫苗反应。该研究还发现，西式饮食或食品添加剂可促进这些细菌增殖，并导致整体炎症状态，使身体更容易发热。这些发现表明，肠道微生物群是疫苗诱导发热的重要驱动因素，提示了肠道靶向微生物群的策略可能 ...

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